Gene Information
Gene NameFLN2
OrganismHomo sapiens (Human)
Gene Length2725
Protein NamesFilamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBNA
Gene CardFLNC
Uniprot IDQ14315
PfamPF00307; PF00630
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:7689010, ECO:0000269|PubMed:9791010}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1V05  (X-ray  1.43A  )  2D7M  (NMR  -  )  2D7N  (NMR  -  )  2D7O  (NMR  -  )  2D7P  (NMR  -  )  2D7Q  (NMR  -  )  2K9U  (NMR  -  )  2NQC  (X-ray  2.05A  )  3V8O  (X-ray  2.80A  )  4MGX  (X-ray  3.16A  )  7OUU  (X-ray  1.47A  )  7OUV  (X-ray  1.80A  )  7P0E  (X-ray  1.60A  ) 
DBSNP rs1562991002  rs387906587  rs387906586  rs1562999443  rs2291569  rs2643766  rs2643767  rs879255639  rs374124083  rs1063261  rs879255640  rs1063262  rs200516164  rs2639142  rs2291572 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:25351925}. Membrane {ECO:0000269|PubMed:11038172};
Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Mouse PG classificationNA
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