| Gene Information | |
|---|---|
| Gene Name | ASMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT) |
| Target Name | acetylserotonin o-methyltransferase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196433 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P46597 |
| Gene Card | ASMT |
| Uniprot ID | P46597 |
| Pfam | PF16864; PF00891 |
| In ASD | no |
| Allosteric Prediction | yes (0.099031157) |
| Ortholog in Animals | Alpaca_ ASMT ( ortholog_one2one ) Dog_ ASMT ( ortholog_one2one ) Macaque_ ASMT ( ortholog_one2one ) Mouse_ Asmt ( ortholog_one2one ) Pig_ ASMT ( ortholog_one2one ) Rat_ Asmt ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASMTL |
| Tissue | pineal.gland |
| Tissue Specificity | Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269|PubMed:22775292, ECO:0000269|PubMed:7989373, ECO:0000269|PubMed:8574683}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4A6D (X-ray 2.40A ) 4A6E (X-ray 2.70A ) |
| DBSNP | rs121918819 rs17149149 rs121918823 rs117343570 rs201053197 rs192710293 rs373339042 rs121918820 rs1215166326 rs121918824 rs201316181 rs148036160 rs121918825 rs121918826 rs146121655 rs121918827 rs1188440875 rs121918821 rs121918828 rs121918822 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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