| Gene Information | |
|---|---|
| Gene Name | FLG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2391 |
| Protein Names | Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000143520 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q5D862 |
| Gene Card | FLG2 |
| Uniprot ID | Q5D862 |
| Pfam | PF01023 |
| In ASD | no |
| Allosteric Prediction | no (-0.289920031) |
| Ortholog in Animals | Alpaca_ FLG2 ( ortholog_one2one ) Macaque_ FLG2 ( ortholog_one2one ) Mouse_ Flg2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HRNR, RPTN, FLG |
| Tissue | skin, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in skin, thymus, stomach and placenta, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, adrenal gland, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea. Weakly expressed in esophagus, tonsils and testis (at protein level). In the skin, strongly expressed in the upper stratum granulosum and lower stratum corneum, but not detected in the upper stratum corneum (at protein level) (PubMed:19384417) (PubMed:21531719). In scalp hair follicles, mainly restricted within the granular and cornified cells surrounding the infundibular outer root sheath, with weak expression in central and proximal outer root sheath (at protein level). Tends to be down-regulated in sporiatic lesions compared to non-lesional skin inthe same patients (PubMed:19384417). {ECO:0000269|PubMed:19384417, ECO:0000269|PubMed:21531719}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs774342933 rs3818831 rs2282304 rs6587667 rs2282303 rs2282302 rs16842865 rs79239476 rs12411129 rs16833974 rs1858484 rs12736606 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19384417}. Cytoplasmic granule {ECO:0000269|PubMed:19384417}. Note=In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. {ECO:0000269|PubMed:19384417, ECO:0000269|PubMed:21531719}. |
| Mouse PG classification | NA |
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