| Gene Information | |
|---|---|
| Gene Name | FLG |
| Organism | Homo sapiens (Human) |
| Gene Length | 4061 |
| Protein Names | Filaggrin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000143631 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | NA |
| Gene Card | FLG |
| Uniprot ID | P20930 |
| Pfam | PF03516; PF01023 |
| In ASD | no |
| Allosteric Prediction | no (-0.499126483) |
| Ortholog in Animals | Alpaca_ FLG ( ortholog_one2one ) Mouse_ Flg ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HRNR, RPTN, FLG2 |
| Tissue | skin, zone.of.skin, lower.leg.skin |
| Tissue Specificity | Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417). {ECO:0000269|PubMed:1429717, ECO:0000269|PubMed:19384417}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4PCW (X-ray 2.20A ) |
| DBSNP | rs41267154 rs11588170 rs2011331 rs11584340 rs3120655 rs3120654 rs3120649 rs11581433 rs12750571 rs11204978 rs12407807 rs12405278 rs3120647 rs12405241 rs12073613 rs12407748 rs3126079 rs142592778 rs7522925 rs7512553 rs2184953 rs3126074 rs148050570 rs3126072 rs759244716 rs2065958 rs2065957 rs3120647 rs528344105 rs7512553 rs11204978 rs2065955 rs12073613 rs113933537 rs12728908 rs571269174 rs7518080 rs3814300 rs12083389 rs9436065 rs3120647 rs537909579 rs11584340 rs7512553 rs776603551 rs768192328 rs755367746 rs146212122 rs140464988 rs3814300 rs3126065 rs3814299 |
| Subcellular location [CC] | Cytoplasmic granule {ECO:0000269|PubMed:16710414}. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). {ECO:0000269|PubMed:1429717, ECO:0000269|PubMed:21531719}. |
| Mouse PG classification | NA |
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