| Gene Information | |
|---|---|
| Gene Name | FLEG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 748 |
| Protein Names | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NCD3 |
| Gene Card | HJURP |
| Uniprot ID | Q8NCD3 |
| Pfam | PF12347; PF12346; PF10384 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. {ECO:0000269|PubMed:17256767, ECO:0000269|PubMed:17823411}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3R45 (X-ray 2.60A ) |
| DBSNP | rs2302154 rs2286430 rs3806589 rs3732215 rs17863822 rs3821238 rs3771333 rs12582 rs10511 |
| Subcellular location [CC] | Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. |
| Mouse PG classification | NA |
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