| Gene Information | |
|---|---|
| Gene Name | FKN |
| Organism | Homo sapiens (Human) |
| Gene Length | 397 |
| Protein Names | Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P78423 |
| Gene Card | CX3CL1 |
| Uniprot ID | P78423 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart. {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B2T (NMR - ) 1F2L (X-ray 2.00A ) 3ONA (X-ray 2.60A ) 4XT1 (X-ray 2.89A ) 4XT3 (X-ray 3.80A ) 5WB2 (X-ray 3.50A ) 7RKF (EM 4.00A ) 7RKM (EM 3.50A ) 7RKN (EM 3.60A ) 7XBX (EM 3.40A ) |
| DBSNP | rs35860084 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9024663}; Single-pass type I membrane protein {ECO:0000255}.; [Processed fractalkine]: Secreted {ECO:0000269|PubMed:9024663}. |
| Mouse PG classification | NA |
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