| Gene Information | |
|---|---|
| Gene Name | AMBRA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1298 |
| Protein Names | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000110497 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9C0C7 |
| Gene Card | AMBRA1 |
| Uniprot ID | Q9C0C7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.431663855) |
| Ortholog in Animals | Alpaca_ AMBRA1 ( ortholog_one2one ) Dog_ AMBRA1 ( ortholog_one2one ) GuineaPig_ AMBRA1 ( ortholog_one2one ) Macaque_ AMBRA1 ( ortholog_one2one ) Mouse_ Ambra1 ( ortholog_one2one ) Pig_ AMBRA1 ( ortholog_one2one ) Rat_ Ambra1 ( ortholog_one2one ) Rabbit_ AMBRA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:20921139}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:A2AH22}. Mitochondrion {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:25215947}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AH22}. Nucleus {ECO:0000269|PubMed:32616651}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:A2AH22}. Note=Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139). Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139). Partially localizes at mitochondria in normal conditions (PubMed:21358617). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617}. |
| Mouse PG classification | NA |
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