| Gene Information | |
|---|---|
| Gene Name | FKBP52 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q02790 |
| Gene Card | FKBP4 |
| Uniprot ID | Q02790 |
| Pfam | PF00254; PF00515; PF07719 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:1279700}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002294(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N1A (X-ray 2.40A ) 1P5Q (X-ray 2.80A ) 1Q1C (X-ray 1.90A ) 1QZ2 (X-ray 3.00A ) 4DRJ (X-ray 1.80A ) 4LAV (X-ray 1.80A ) 4LAW (X-ray 2.40A ) 4LAX (X-ray 2.01A ) 4LAY (X-ray 1.70A ) 4TW8 (X-ray 3.00A ) 6RCY (X-ray 2.30A ) |
| DBSNP | rs1042228 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}. |
| Mouse PG classification | NA |
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