| Gene Information | |
|---|---|
| Gene Name | FKBP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000096060 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13451 |
| Gene Card | FKBP5 |
| Uniprot ID | Q13451 |
| Pfam | PF00254; PF00515; PF13181 |
| In ASD | no |
| Allosteric Prediction | yes (0.592568291) |
| Ortholog in Animals | Alpaca_ FKBP5 ( ortholog_one2one ) GuineaPig_ FKBP5 ( ortholog_one2one ) Macaque_ FKBP5 ( ortholog_one2one ) Mouse_ Fkbp5 ( ortholog_one2one ) Pig_ FKBP5 ( ortholog_one2one ) Rat_ Fkbp5 ( ortholog_one2one ) Rabbit_ FKBP5 ( ortholog_one2one ) |
| Ohnologs | FKBP4 |
| Paralogs | FKBP11, FKBP14, FKBP3, TTC9, FKBP10, FKBP1A, FKBP1C, FKBP1B, FKBP7, FKBP2, FKBP8, TTC9B, TTC9C, FKBPL, FKBP4, FKBP15, FKBP9, FKBP6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001293(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KT0 (X-ray 2.70A ) 3O5D (X-ray 4.00A ) 3O5E (X-ray 1.60A ) 3O5F (X-ray 1.65A ) 3O5G (X-ray 2.00A ) 3O5I (X-ray 1.80A ) 3O5J (X-ray 1.70A ) 3O5K (X-ray 2.70A ) 3O5L (X-ray 1.30A ) 3O5M (X-ray 1.60A ) 3O5O (X-ray 1.15A ) 3O5P (X-ray 1.00A ) 3O5Q (X-ray 0.96A ) 3O5R (X-ray 1.10A ) 4DRH (X-ray 2.30A ) 4DRI (X-ray 1.45A ) 4DRK (X-ray 1.50A ) 4DRM (X-ray 1.48A ) 4DRN (X-ray 1.07A ) 4DRO (X-ray 1.10A ) 4DRP (X-ray 1.80A ) 4DRQ (X-ray 1.00A ) 4JFI (X-ray 1.05A ) 4JFJ (X-ray 1.08A ) 4JFK (X-ray 1.15A ) 4JFL (X-ray 1.20A ) 4JFM (X-ray 1.02A ) 4R0X (X-ray 1.20A ) 4TW6 (X-ray 1.40A ) 4TW7 (X-ray 1.25A ) 4TX0 (X-ray 1.03A ) 4W9O (X-ray 1.27A ) 4W9P (X-ray 1.50A ) 4W9Q (X-ray 1.08A ) 5BXJ (X-ray 1.24A ) 5DIT (X-ray 2.25A ) 5DIU (X-ray 1.30A ) 5DIV (X-ray 1.65A ) 5NJX (X-ray 2.49A ) 5OBK (X-ray 1.00A ) 5OMP (X-ray 1.88A ) 6SAF (X-ray 2.05A ) 6TX4 (X-ray 1.06A ) 6TX5 (X-ray 1.08A ) 6TX6 (X-ray 0.98A ) 6TX7 (X-ray 1.13A ) 6TX8 (X-ray 1.20A ) 6TX9 (X-ray 1.42A ) 6TXX (X-ray 2.10A ) 7A6W (X-ray 1.85A ) 7A6X (X-ray 1.67A ) 7AOT (X-ray 0.85A ) 7AOU (X-ray 1.16A ) 7APQ (X-ray 1.09A ) 7APS (X-ray 0.94A ) 7APT (X-ray 1.13A ) 7APW (X-ray 0.89A ) 7AWF (X-ray 1.40A ) 7AWX (X-ray 2.20A ) 7B9Y (X-ray 1.35A ) 7B9Z (X-ray 1.44A ) 7BA0 (X-ray 1.14A ) 7ETT (X-ray 1.50A ) 7ETU (X-ray 1.39A ) 7ETV (X-ray 1.31A ) 7L7I (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}. |
| Mouse PG classification | NA |
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