| Gene Information | |
|---|---|
| Gene Name | FKBP1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 108 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) |
| Target Name | peptidyl-prolyl cis-trans isomerase fkbp1a |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000088832 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P62942 |
| Gene Card | FKBP1A |
| Uniprot ID | P62942 |
| Pfam | PF00254 |
| In ASD | yes |
| Allosteric Prediction | yes (0.864462676) |
| Ortholog in Animals | Alpaca_ FKBP1A ( ortholog_one2one ) Dog_ FKBP1A ( ortholog_many2many ) Macaque_ FKBP1A ( ortholog_one2one ) Mouse_ Fkbp1a ( ortholog_one2many ) Rat_ Fkbp1a ( ortholog_one2many ) |
| Ohnologs | FKBP1B |
| Paralogs | FKBP11, FKBP14, FKBP3, TTC9, FKBP10, FKBP7, FKBP2, FKBP8, TTC9B, TTC9C, FKBPL, FKBP5, FKBP4, FKBP15, FKBP9, FKBP6, FKBP1C, FKBP1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.005765(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A7X (X-ray 2.00A ) 1B6C (X-ray 2.60A ) 1BKF (X-ray 1.60A ) 1BL4 (X-ray 1.90A ) 1D6O (X-ray 1.85A ) 1D7H (X-ray 1.90A ) 1D7I (X-ray 1.90A ) 1D7J (X-ray 1.85A ) 1EYM (X-ray 2.00A ) 1F40 (NMR - ) 1FAP (X-ray 2.70A ) 1FKB (X-ray 1.70A ) 1FKD (X-ray 1.72A ) 1FKF (X-ray 1.70A ) 1FKG (X-ray 2.00A ) 1FKH (X-ray 1.95A ) 1FKI (X-ray 2.20A ) 1FKJ (X-ray 1.70A ) 1FKR (NMR - ) 1FKS (NMR - ) 1FKT (NMR - ) 1J4H (X-ray 1.80A ) 1J4I (X-ray 1.80A ) 1J4R (X-ray 1.80A ) 1NSG (X-ray 2.20A ) 1QPF (X-ray 2.50A ) 1QPL (X-ray 2.90A ) 2DG3 (X-ray 1.70A ) 2DG4 (X-ray 1.70A ) 2DG9 (X-ray 1.70A ) 2FAP (X-ray 2.20A ) 2FKE (X-ray 1.72A ) 2ND5 (NMR - ) 2PPN (X-ray 0.92A ) 2PPO (X-ray 1.29A ) 2PPP (X-ray 0.94A ) 2RSE (NMR - ) 3FAP (X-ray 1.85A ) 3H9R (X-ray 2.35A ) 3MDY (X-ray 2.05A ) 4DH0 (X-ray 2.10A ) 4FAP (X-ray 2.80A ) 4IPX (X-ray 1.70A ) 4N19 (X-ray 1.20A ) 4ODP (X-ray 1.75A ) 4ODQ (X-ray 2.00A ) 4ODR (X-ray 1.93A ) 5I7P (X-ray 2.00A ) 5I7Q (X-ray 1.90A ) 6I1S (X-ray 1.52A ) 6M4U (X-ray 2.20A ) 6OQA (X-ray 2.20A ) 6VCU (X-ray 1.69A ) 6YF0 (X-ray 1.55A ) 6YF1 (X-ray 1.12A ) 6YF2 (X-ray 1.03A ) 6YF3 (X-ray 1.00A ) 7EPD (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:1701173}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}. |
| Mouse PG classification | NA |
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