Gene Information
Gene NameFISH
OrganismHomo sapiens (Human)
Gene Length1133
Protein NamesSH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ5TCZ1
Gene CardSH3PXD2A
Uniprot IDQ5TCZ1
PfamPF00787; PF00018
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityFound in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DNU  (NMR  2EGA  (NMR  2EGC  (NMR  2EKH  (NMR 
DBSNP rs11818820  rs3781365  rs12764700 
Subcellular location [CC]Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Mouse PG classificationNA
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