| Gene Information | |
|---|---|
| Gene Name | DPYSL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 572 |
| Protein Names | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) |
| Target Name | dihydropyrimidinase related protein 2 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000092964 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q16555 |
| Gene Card | DPYSL2 |
| Uniprot ID | Q16555 |
| Pfam | PF01979 |
| In ASD | no |
| Allosteric Prediction | yes (0.362485267) |
| Ortholog in Animals | Alpaca_ DPYSL2 ( ortholog_one2one ) Dog_ DPYSL2 ( ortholog_one2one ) GuineaPig_ DPYSL2 ( ortholog_one2one ) Macaque_ DPYSL2 ( ortholog_one2one ) Mouse_ Dpysl2 ( ortholog_one2one ) Pig_ DPYSL2 ( ortholog_one2one ) Rat_ Dpysl2 ( ortholog_one2one ) Rabbit_ DPYSL2 ( ortholog_one2one ) |
| Ohnologs | DPYS, DPYSL4, CRMP1, DPYSL3 |
| Paralogs | DPYSL4, DPYSL3, CRMP1, DPYSL5, DPYS |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.050953(Mouse);NULL(Rat);0.052405(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2GSE (X-ray 2.40A ) 2VM8 (X-ray 1.90A ) 5LXX (X-ray 1.25A ) 5MKV (X-ray 1.80A ) 5MLE (X-ray 2.48A ) 5X1A (X-ray 1.82A ) 5X1C (X-ray 2.10A ) 5X1D (X-ray 2.20A ) 5YZ5 (X-ray 1.80A ) 5YZA (X-ray 2.30A ) 5YZB (X-ray 2.80A ) 6JV9 (X-ray 2.26A ) 6JVB (X-ray 2.00A ) 7X68 (X-ray 1.80A ) |
| DBSNP | rs2228979 rs1337153084 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes. |
| Mouse PG classification | NA |
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