| Gene Information | |
|---|---|
| Gene Name | NEDD4L |
| Organism | Homo sapiens (Human) |
| Gene Length | 975 |
| Protein Names | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000049759 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96PU5 |
| Gene Card | NEDD4L |
| Uniprot ID | Q96PU5 |
| Pfam | PF00168; PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | yes (0.854861076) |
| Ortholog in Animals | Alpaca_ NEDD4L ( ortholog_one2one ) Dog_ NEDD4L ( ortholog_one2one ) GuineaPig_ NEDD4L ( ortholog_one2one ) Macaque_ NEDD4L ( ortholog_one2one ) Mouse_ Nedd4l ( ortholog_one2one ) Pig_ NEDD4L ( ortholog_one2one ) Rat_ Nedd4l ( ortholog_one2one ) Rabbit_ NEDD4L ( ortholog_one2one ) |
| Ohnologs | NEDD4 |
| Paralogs | HERC4, NEDD4, HECTD1, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in prostate, pancreas, and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:14615060, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:19664597, ECO:0000269|PubMed:23999003}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LAJ (NMR - ) 2LB2 (NMR - ) 2LTY (NMR - ) 2MPT (NMR - ) 2NSQ (X-ray 1.85A ) 2ONI (X-ray 2.20A ) 3JVZ (X-ray 3.30A ) 3JW0 (X-ray 3.10A ) 5HPK (X-ray 2.43A ) 6ZBT (X-ray 1.80A ) 6ZC9 (X-ray 1.90A ) 7LP1 (X-ray 1.35A ) 7LP2 (X-ray 1.88A ) 7LP3 (X-ray 1.61A ) 7LP4 (NMR - ) 7LP5 (NMR - ) 7NMZ (X-ray 2.30A ) |
| DBSNP | rs767136811 rs879255599 rs879255598 rs879255597 rs879255596 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:18819914, ECO:0000269|PubMed:27694961}. Golgi apparatus {ECO:0000269|PubMed:26363003}. Endosome, multivesicular body {ECO:0000269|PubMed:26363003}. Note=May be recruited to exosomes by NDFIP1. |
| Mouse PG classification | NA |
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