| Gene Information | |
|---|---|
| Gene Name | FHIT |
| Organism | Homo sapiens (Human) |
| Gene Length | 147 |
| Protein Names | Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein) |
| Target Name | fragile histidine triad protein |
| Target Type | Successful target |
| Gene Age | 101 ( ENSG00000189283 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49789 |
| Gene Card | FHIT |
| Uniprot ID | P49789 |
| Pfam | PF01230 |
| In ASD | no |
| Allosteric Prediction | yes (0.047127715) |
| Ortholog in Animals | Alpaca_ FHIT ( ortholog_one2one ) Dog_ FHIT ( ortholog_one2one ) GuineaPig_ FHIT ( ortholog_one2one ) Macaque_ FHIT ( ortholog_one2one ) Mouse_ Fhit ( ortholog_one2one ) Pig_ FHIT ( ortholog_one2one ) Rat_ Fhit ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HINT1, HINT2 |
| Tissue | NA |
| Tissue Specificity | Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FHI (X-ray 3.10A ) 1FIT (X-ray 1.85A ) 2FHI (X-ray 2.60A ) 2FIT (X-ray 1.90A ) 3FIT (X-ray 2.40A ) 4FIT (X-ray 2.50A ) 5FIT (X-ray 2.30A ) 6FIT (X-ray 2.60A ) 7P8P (X-ray 2.34A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15007172, ECO:0000269|PubMed:15313915}. Mitochondrion {ECO:0000269|PubMed:19622739}. Nucleus {ECO:0000269|PubMed:15313915}. |
| Mouse PG classification | NA |
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