| Gene Information | |
|---|---|
| Gene Name | ITIH4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 930 |
| Protein Names | Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] |
| Target Name | inter-alpha-trypsin inhibitor heavy chain h4 |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000055955 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14624 |
| Gene Card | ITIH4 |
| Uniprot ID | Q14624 |
| Pfam | PF06668; PF08487; PF00092 |
| In ASD | no |
| Allosteric Prediction | yes (0.339113226) |
| Ortholog in Animals | Alpaca_ ITIH4 ( ortholog_one2one ) Dog_ ITIH4 ( ortholog_one2one ) GuineaPig_ ITIH4 ( ortholog_one2one ) Macaque_ ITIH4 ( ortholog_one2one ) Mouse_ Itih4 ( ortholog_one2one ) Pig_ ITIH4 ( ortholog_one2one ) Rat_ Itih4 ( ortholog_one2one ) Rabbit_ ITIH4 ( ortholog_one2one ) |
| Ohnologs | ITIH6, ITIH5, ITIH2 |
| Paralogs | VWA5A, VWA5B2, ITIH3, ITIH5, VWA5B1, ITIH2, VWA3B, PARP4, ITIH6, ITIH1, VWA3A |
| Tissue | pancreas, liver |
| Tissue Specificity | Liver specific. {ECO:0000269|PubMed:7775381, ECO:0000269|PubMed:7805892}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs13072536 rs2276814 rs4687657 rs2256734 rs2535621 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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