| Gene Information | |
|---|---|
| Gene Name | FGG |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Fibrinogen gamma chain |
| Target Name | fibrinogen |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171557 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02679 |
| Gene Card | FGG |
| Uniprot ID | P02679 |
| Pfam | PF08702; PF00147 |
| In ASD | yes |
| Allosteric Prediction | yes (1.220262433) |
| Ortholog in Animals | Alpaca_ FGG ( ortholog_one2one ) Dog_ FGG ( ortholog_one2one ) GuineaPig_ FGG ( ortholog_one2one ) Macaque_ FGG ( ortholog_one2one ) Mouse_ Fgg ( ortholog_one2one ) Pig_ FGG ( ortholog_one2one ) Rat_ Fgg ( ortholog_one2one ) Rabbit_ FGG ( ortholog_one2one ) |
| Ohnologs | FGL1 |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, ANGPT1, FN1, ANGPT2 |
| Tissue | liver, brain, kidney |
| Tissue Specificity | Detected in blood plasma (at protein level). {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1DUG (X-ray 1.80A ) 1FIB (X-ray 2.10A ) 1FIC (X-ray 2.50A ) 1FID (X-ray 2.10A ) 1FZA (X-ray 2.90A ) 1FZB (X-ray 2.90A ) 1FZC (X-ray 2.30A ) 1FZE (X-ray 3.00A ) 1FZF (X-ray 2.70A ) 1FZG (X-ray 2.50A ) 1LT9 (X-ray 2.80A ) 1LTJ (X-ray 2.80A ) 1N86 (X-ray 3.20A ) 1N8E (X-ray 4.50A ) 1RE3 (X-ray 2.45A ) 1RE4 (X-ray 2.70A ) 1RF0 (X-ray 2.81A ) 1RF1 (X-ray 2.53A ) 2A45 (X-ray 3.65A ) 2FFD (X-ray 2.89A ) 2FIB (X-ray 2.01A ) 2H43 (X-ray 2.70A ) 2HLO (X-ray 2.60A ) 2HOD (X-ray 2.90A ) 2HPC (X-ray 2.90A ) 2HWL (X-ray 2.40A ) 2OYH (X-ray 2.40A ) 2OYI (X-ray 2.70A ) 2Q9I (X-ray 2.80A ) 2VDO (X-ray 2.51A ) 2VDP (X-ray 2.80A ) 2VDQ (X-ray 2.59A ) 2VDR (X-ray 2.40A ) 2VR3 (X-ray 1.95A ) 2XNX (X-ray 3.30A ) 2XNY (X-ray 7.50A ) 2Y7L (X-ray 1.49A ) 2Z4E (X-ray 2.70A ) 3BVH (X-ray 2.60A ) 3E1I (X-ray 2.30A ) 3FIB (X-ray 2.10A ) 3GHG (X-ray 2.90A ) 3H32 (X-ray 3.60A ) 3HUS (X-ray 3.04A ) 4B60 (X-ray 1.83A ) |
| DBSNP | rs11551835 rs2066870 rs6063 rs121913087 rs121913088 rs121913089 rs121913090 rs121913091 rs121913092 rs121913094 rs121913093 rs75848804 rs75848804 rs587777720 rs6061 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Mouse PG classification | HPG |
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