Gene Information
Gene NameFCRL6
OrganismHomo sapiens (Human)
Gene Length434
Protein NamesFc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)
Target NameNA
Target TypeNA
Gene Age132 ( ENSG00000181036 )
Evolutionary StageMammalia
AlphaFoldDBQ6DN72
Gene CardFCRL6
Uniprot IDQ6DN72
PfamPF13895
In ASDno
Allosteric Predictionno (-0.984108531)
Ortholog in AnimalsAlpaca_ FCRL6 ( ortholog_one2one )
Dog_ FCRL6 ( ortholog_one2one )
Macaque_ FCRL6 ( ortholog_one2one )
Pig_ FCRL6 ( ortholog_one2one )
OhnologsNA
ParalogsPECAM1, C17orf99, FCRLA, FCRLB, FCGR3B, FCGR2A, FCGR2B, FCGR3A, FCGR1A, FCER1A, FCGR2C, FCRL5, FCRL4, MILR1, FCRL2, FCRL3, FCRL1
Tissuespleen
Tissue SpecificityExpressed by cytolytic cells including NK cells, effector and effector-memory CD8(+) T-cells, and a subset of NKT cells (at protein level) (PubMed:17213291, PubMed:18991291, PubMed:20933011). Also expressed in gamma delta T cells and in a rare subset of effector CD4(+) T-cells (at protein level) (PubMed:18991291). Expressed in spleen, skin, peripheral blood leukocytes, liver, lung, bone marrow, small intestine and placenta (PubMed:20933011). Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8(+) T-cells but also populations of CD4(+) T-cells (PubMed:17213291, PubMed:20933011). Expression among CD8(+) T-cells and NK cells is expanded in individuals with chronic lymphocytic leukemia (CLL) but is reduced in PBMCs from patients with acute (AML), chronic myeloid leukemia (CML) and non-Hodgkin's lymphoma (PubMed:18991291, PubMed:20933011). Expression is higher in PBMCs and/or CD3(+) cells of patients with autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia purpura (ITP) (PubMed:20933011). In contrast, expression in CD3(+) cells from patients with lupus anticoagulans (LA) is higher (PubMed:20933011). {ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20933011}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs4443889 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20933011};
Single-pass type I membrane protein {ECO:0000305}.
Mouse PG classificationNA
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