| Gene Information | |
|---|---|
| Gene Name | RHOA |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) |
| Target Name | transforming protein rhoa |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000067560 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P61586 |
| Gene Card | RHOA |
| Uniprot ID | P61586 |
| Pfam | PF00071 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00016244) |
| Ortholog in Animals | Alpaca_ RHOA ( ortholog_one2one ) Dog_ RHOA ( ortholog_one2one ) GuineaPig_ RHOA ( ortholog_one2one ) Macaque_ RHOA ( ortholog_one2one ) Mouse_ Rhoa ( ortholog_one2one ) Pig_ RHOA ( ortholog_one2one ) Rat_ Rhoa ( ortholog_one2one ) Rabbit_ RHOA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RHOB, RHOC, RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001644(Rat);0.011321(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A2B (X-ray 2.40A ) 1CC0 (X-ray 5.00A ) 1CXZ (X-ray 2.20A ) 1DPF (X-ray 2.00A ) 1FTN (X-ray 2.10A ) 1KMQ (X-ray 1.55A ) 1LB1 (X-ray 2.81A ) 1OW3 (X-ray 1.80A ) 1S1C (X-ray 2.60A ) 1TX4 (X-ray 1.65A ) 1X86 (X-ray 3.22A ) 1XCG (X-ray 2.50A ) 2RGN (X-ray 3.50A ) 3KZ1 (X-ray 2.70A ) 3LW8 (X-ray 1.85A ) 3LWN (X-ray 2.28A ) 3LXR (X-ray 1.68A ) 3MSX (X-ray 1.65A ) 3T06 (X-ray 2.84A ) 4D0N (X-ray 2.10A ) 4XH9 (X-ray 2.00A ) 4XOI (X-ray 2.09A ) 4XSG (X-ray 1.80A ) 4XSH (X-ray 2.50A ) 5A0F (X-ray 2.00A ) 5BWM (X-ray 2.50A ) 5C2K (X-ray 1.42A ) 5C4M (X-ray 1.30A ) 5EZ6 (X-ray 1.80A ) 5FR1 (X-ray 2.75A ) 5FR2 (X-ray 3.35A ) 5HPY (X-ray 2.40A ) 5IRC (X-ray 1.72A ) 5JCP (X-ray 2.10A ) 5JHG (X-ray 2.50A ) 5JHH (X-ray 2.30A ) 5M6X (X-ray 2.40A ) 5M70 (X-ray 2.20A ) 5ZHX (X-ray 3.50A ) 6BC0 (X-ray 2.20A ) 6BCA (X-ray 2.00A ) 6BCB (X-ray 1.40A ) 6KX2 (X-ray 1.45A ) 6KX3 (X-ray 1.98A ) 6R3V (X-ray 1.75A ) 6V6M (X-ray 1.39A ) 6V6U (X-ray 1.16A ) 6V6V (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QUI0}. Nucleus {ECO:0000269|PubMed:12551911}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. {ECO:0000250|UniProtKB:Q9QUI0}. |
| Mouse PG classification | NA |
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