Gene Information
Gene NameFGFBP1
OrganismHomo sapiens (Human)
Gene Length234
Protein NamesFibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000137440 )
Evolutionary StageVertebrata
AlphaFoldDBQ14512
Gene CardFGFBP1
Uniprot IDQ14512
PfamPF06473
In ASDno
Allosteric Predictionno (-0.90241186)
Ortholog in AnimalsAlpaca_ FGFBP1 ( ortholog_one2one )
Dog_ FGFBP1 ( ortholog_one2one )
GuineaPig_ FGFBP1 ( ortholog_one2one )
Macaque_ FGFBP1 ( ortholog_one2one )
Mouse_ Fgfbp1 ( ortholog_one2one )
Pig_ FGFBP1 ( ortholog_one2one )
Rat_ Fgfbp1 ( ortholog_one2one )
Rabbit_ FGFBP1 ( ortholog_one2one )
OhnologsNA
ParalogsFGFBP2, FGFBP3
Tissueesophagus, esophagus.mucosa
Tissue SpecificityExpressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Secreted, extracellular space {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Cell membrane {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171};
Peripheral membrane protein {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. {ECO:0000269|PubMed:11148217}.
Mouse PG classificationNA
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