| Gene Information | |
|---|---|
| Gene Name | CTSV |
| Organism | Homo sapiens (Human) |
| Gene Length | 334 |
| Protein Names | Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V) |
| Target Name | cathepsin l2 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000136943 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60911 |
| Gene Card | CTSV |
| Uniprot ID | O60911 |
| Pfam | PF08246; PF00112 |
| In ASD | no |
| Allosteric Prediction | no (-0.148689343) |
| Ortholog in Animals | Alpaca_ CTSV ( ortholog_one2one ) Alpaca_ CTSV ( ortholog_one2many ) Dog_ CTSL ( ortholog_one2many ) GuineaPig_ CTSV ( ortholog_one2one ) Macaque_ CTSV ( ortholog_one2one ) Pig_ CTSV ( ortholog_one2one ) Rat_ Ctsl ( ortholog_one2one ) Rabbit_ CTSV ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CTSK, CTSH, TINAGL1, CTSO, CTSW, CTSF, TINAG, CTSB, CTSC, CTSZ, CTSS, CTSL |
| Tissue | skin, testis, heart, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9563472, ECO:0000269|PubMed:9727401}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1FH0 (X-ray 1.60A ) 3H6S (X-ray 2.22A ) 3KFQ (X-ray 1.99A ) |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome {ECO:0000305}. |
| Mouse PG classification | NA |
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