| Gene Information | |
|---|---|
| Gene Name | FGFB |
| Organism | Homo sapiens (Human) |
| Gene Length | 288 |
| Protein Names | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P09038 |
| Gene Card | FGF2 |
| Uniprot ID | P09038 |
| Pfam | PF00167 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. {ECO:0000269|PubMed:1417798, ECO:0000269|PubMed:1721615}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002808(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BAS (X-ray 1.90A ) 1BFB (X-ray 1.90A ) 1BFC (X-ray 2.20A ) 1BFF (X-ray 2.00A ) 1BFG (X-ray 1.60A ) 1BLA (NMR - ) 1BLD (NMR - ) 1CVS (X-ray 2.80A ) 1EV2 (X-ray 2.20A ) 1FGA (X-ray 2.20A ) 1FQ9 (X-ray 3.00A ) 1II4 (X-ray 2.70A ) 1IIL (X-ray 2.30A ) 2BFH (X-ray 2.50A ) 2FGF (X-ray 1.77A ) 2M49 (NMR - ) 4FGF (X-ray 1.60A ) 4OEE (X-ray 1.50A ) 4OEF (X-ray 1.80A ) 4OEG (X-ray 1.60A ) 5X1O (X-ray 1.90A ) 6L4O (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:20230531}. Nucleus {ECO:0000269|PubMed:22321063}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). {ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:22321063}. |
| Mouse PG classification | NA |
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