| Gene Information | |
|---|---|
| Gene Name | FGFA |
| Organism | Homo sapiens (Human) |
| Gene Length | 155 |
| Protein Names | Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P05230 |
| Gene Card | FGF1 |
| Uniprot ID | P05230 |
| Pfam | PF00167 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. {ECO:0000269|PubMed:11964394, ECO:0000269|PubMed:7504343}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AXM (X-ray 3.00A ) 1DJS (X-ray 2.40A ) 1DZC (NMR - ) 1DZD (NMR - ) 1E0O (X-ray 2.80A ) 1EVT (X-ray 2.80A ) 1HKN (X-ray 2.00A ) 1JQZ (X-ray 1.65A ) 1JT3 (X-ray 1.95A ) 1JT4 (X-ray 1.78A ) 1JT5 (X-ray 1.85A ) 1JT7 (X-ray 1.70A ) 1JTC (X-ray 1.70A ) 1JY0 (X-ray 1.70A ) 1K5U (X-ray 2.00A ) 1K5V (X-ray 2.10A ) 1M16 (X-ray 1.70A ) 1NZK (X-ray 1.95A ) 1P63 (X-ray 1.60A ) 1PZZ (X-ray 2.00A ) 1Q03 (X-ray 2.05A ) 1Q04 (X-ray 1.80A ) 1RG8 (X-ray 1.10A ) 1RML (NMR - ) 1RY7 (X-ray 3.20A ) 1YTO (X-ray 2.10A ) 1Z2V (X-ray 1.90A ) 1Z4S (X-ray 2.60A ) 2AFG (X-ray 2.00A ) 2AQZ (X-ray 1.85A ) 2AXM (X-ray 3.00A ) 2ERM (NMR - ) 2HW9 (X-ray 1.60A ) 2HWA (X-ray 1.65A ) 2HWM (X-ray 1.60A ) 2HZ9 (X-ray 1.70A ) 2K43 (NMR - ) 2K4A (NMR - ) 2K8R (NMR - ) 2KI4 (NMR - ) 2KI6 (NMR - ) 2NTD (X-ray 2.52A ) 2Q9X (X-ray 1.70A ) 2RQ9 (NMR - ) 3B9U (X-ray 1.55A ) 3BA4 (X-ray 1.80A ) 3BA5 (X-ray 1.75A ) 3BA7 (X-ray 1.60A ) 3BAD (X-ray 2.00A ) 3BAG (X-ray 1.75A ) 3BAH (X-ray 1.65A ) 3BAO (X-ray 1.55A ) 3BAQ (X-ray 1.80A ) 3BAU (X-ray 1.60A ) 3BAV (X-ray 1.62A ) 3BB2 (X-ray 1.50A ) 3CQA (X-ray 1.80A ) 3CRG (X-ray 1.85A ) 3CRH (X-ray 2.15A ) 3CRI (X-ray 2.10A ) 3CU1 (X-ray 2.60A ) 3FGM (X-ray 1.95A ) 3FJ8 (X-ray 2.00A ) 3FJ9 (X-ray 1.90A ) 3FJA (X-ray 1.95A ) 3FJB (X-ray 2.00A ) 3FJC (X-ray 2.00A ) 3FJD (X-ray 1.90A ) 3FJE (X-ray 2.10A ) 3FJF (X-ray 1.90A ) 3FJH (X-ray 1.90A ) 3FJI (X-ray 2.55A ) 3FJJ (X-ray 1.90A ) 3FJK (X-ray 2.15A ) 3HOM (X-ray 2.30A ) 3JUT (X-ray 2.25A ) 3K1X (X-ray 1.98A ) 3O3Q (X-ray 1.60A ) 3OJ2 (X-ray 2.20A ) 3OJM (X-ray 2.10A ) 3OJV (X-ray 2.60A ) 3UD7 (X-ray 2.80A ) 3UD8 (X-ray 2.37A ) 3UD9 (X-ray 2.34A ) 3UDA (X-ray 2.51A ) 4J23 (X-ray 3.88A ) 4Q91 (X-ray 1.80A ) 4Q9G (X-ray 1.55A ) 4Q9P (X-ray 1.80A ) 4QAL (X-ray 1.50A ) 4QBC (X-ray 1.52A ) 4QBV (X-ray 1.50A ) 4QC4 (X-ray 1.49A ) 4QO3 (X-ray 2.05A ) 4XKI (X-ray 2.00A ) 4YOL (X-ray 1.97A ) |
| DBSNP | rs17223632 |
| Subcellular location [CC] | Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}. |
| Mouse PG classification | NA |
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