| Gene Information | |
|---|---|
| Gene Name | FGF23 |
| Organism | Homo sapiens (Human) |
| Gene Length | 251 |
| Protein Names | Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] |
| Target Name | fibroblast growth factor-23 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000118972 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9GZV9 |
| Gene Card | FGF23 |
| Uniprot ID | Q9GZV9 |
| Pfam | PF00167 |
| In ASD | no |
| Allosteric Prediction | yes (0.641808365) |
| Ortholog in Animals | Alpaca_ FGF23 ( ortholog_one2one ) Dog_ FGF23 ( ortholog_one2one ) GuineaPig_ FGF23 ( ortholog_one2one ) Macaque_ FGF23 ( ortholog_one2one ) Mouse_ Fgf23 ( ortholog_one2one ) Pig_ FGF23 ( ortholog_one2one ) Rat_ Fgf23 ( ortholog_one2one ) Rabbit_ FGF23 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FGF1, FGF16, FGF14, FGF21, FGF3, FGF10, FGF5, FGF9, FGF7, FGF22, FGF6, FGF19, FGF17, FGF13, FGF8, FGF18, FGF11, FGF12, FGF20, FGF2, FGF4 |
| Tissue | NA |
| Tissue Specificity | Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). {ECO:0000269|PubMed:12952917}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2P39 (X-ray 1.50A ) 5W21 (X-ray 3.00A ) 6S22 (X-ray 1.96A ) |
| DBSNP | rs104894342 rs104894343 rs104894344 rs772964687 rs104894347 rs193922702 rs28937882 rs13312793 rs7955866 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation. |
| Mouse PG classification | NA |
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