| Gene Information | |
|---|---|
| Gene Name | FGF21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 209 |
| Protein Names | Fibroblast growth factor 21 (FGF-21) |
| Target Name | fibroblast growth factor-21 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000105550 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NSA1 |
| Gene Card | FGF21 |
| Uniprot ID | Q9NSA1 |
| Pfam | PF00167 |
| In ASD | no |
| Allosteric Prediction | yes (0.173202143) |
| Ortholog in Animals | Alpaca_ FGF21 ( ortholog_one2one ) Dog_ FGF21 ( ortholog_one2one ) GuineaPig_ FGF21 ( ortholog_one2one ) Macaque_ FGF21 ( ortholog_one2one ) Mouse_ Fgf21 ( ortholog_one2one ) Pig_ FGF21 ( ortholog_one2one ) Rat_ Fgf21 ( ortholog_one2one ) Rabbit_ FGF21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FGF1, FGF16, FGF14, FGF3, FGF10, FGF5, FGF9, FGF7, FGF22, FGF6, FGF23, FGF19, FGF17, FGF13, FGF8, FGF18, FGF11, FGF12, FGF20, FGF2, FGF4 |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VAQ (X-ray 2.61A ) 6M6E (NMR - ) 6M6F (NMR - ) |
| DBSNP | rs41308776 rs739320 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:Q9JJN1}. |
| Mouse PG classification | NA |
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