| Gene Information | |
|---|---|
| Gene Name | EMC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 210 |
| Protein Names | ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000131148 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43402 |
| Gene Card | EMC8 |
| Uniprot ID | O43402 |
| Pfam | PF03665 |
| In ASD | no |
| Allosteric Prediction | no (-1.073727191) |
| Ortholog in Animals | Alpaca_ EMC8 ( ortholog_one2one ) Dog_ EMC8 ( ortholog_one2one ) GuineaPig_ EMC8 ( ortholog_one2one ) Macaque_ EMC8 ( ortholog_one2one ) Mouse_ Emc8 ( ortholog_one2one ) Rat_ Emc8 ( ortholog_one2one ) |
| Ohnologs | EMC9 |
| Paralogs | EMC9 |
| Tissue | NA |
| Tissue Specificity | Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.019576(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WW7 (EM 3.40A ) 7ADO (EM 3.39A ) 7ADP (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Peripheral membrane protein {ECO:0000305|PubMed:32439656}; Cytoplasmic side {ECO:0000269|PubMed:32439656}. |
| Mouse PG classification | NA |
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