| Gene Information | |
|---|---|
| Gene Name | LCT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1927 |
| Protein Names | Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] |
| Target Name | lactase-phlorizin hydrolase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115850 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P09848 |
| Gene Card | LCT |
| Uniprot ID | P09848 |
| Pfam | PF00232 |
| In ASD | no |
| Allosteric Prediction | yes (0.551116971) |
| Ortholog in Animals | Alpaca_ LCT ( ortholog_one2one ) Dog_ LCT ( ortholog_one2one ) Macaque_ LCT ( ortholog_one2one ) Mouse_ Lct ( ortholog_one2one ) Rat_ Lct ( ortholog_one2one ) Rabbit_ LCT ( ortholog_one2many ) |
| Ohnologs | KLB |
| Paralogs | GBA3, LCTL, KLB, KL |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Specifically expressed in small intestine. {ECO:0000269|PubMed:2460343}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35156533 rs3754689 rs121908937 rs4954449 rs386833833 rs35891837 rs2322659 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:9593732}; Single-pass type I membrane protein {ECO:0000305|PubMed:9593732}. Note=Brush border. {ECO:0000250|UniProtKB:P09849}. |
| Mouse PG classification | NA |
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