| Gene Information | |
|---|---|
| Gene Name | DHCR7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 475 |
| Protein Names | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) |
| Target Name | 7-dehydrocholesterol reductase |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000172893 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBM7 |
| Gene Card | DHCR7 |
| Uniprot ID | Q9UBM7 |
| Pfam | PF01222 |
| In ASD | no |
| Allosteric Prediction | yes (0.752834469) |
| Ortholog in Animals | Alpaca_ DHCR7 ( ortholog_one2one ) Dog_ DHCR7 ( ortholog_one2one ) GuineaPig_ DHCR7 ( ortholog_one2one ) Macaque_ DHCR7 ( ortholog_one2one ) Mouse_ Dhcr7 ( ortholog_one2one ) Pig_ DHCR7 ( ortholog_one2one ) Rat_ Dhcr7 ( ortholog_one2one ) |
| Ohnologs | LBR |
| Paralogs | LBR, TM7SF2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Most abundant in adrenal gland, liver, testis, and brain. {ECO:0000269|PubMed:9465114, ECO:0000269|PubMed:9878250}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1127869 rs104886035 rs104886038 rs80338853 rs104886041 rs104886040 rs121912195 rs28938174 rs1555146475 rs777425801 rs143312232 rs753960624 rs80338855 rs536394774 rs1555146061 rs80338856 rs80338857 rs121909764 rs886041354 rs104894212 rs398123607 rs121909765 rs1173707321 rs80338859 rs121909768 rs80338860 rs371302153 rs373306653 rs779709646 rs773134475 rs61757582 rs61757582 rs1046560765 rs80338862 rs80338862 rs760242 rs1354718634 rs535561852 rs751604696 rs80338864 rs80338864 rs542266962 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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