| Gene Information | |
|---|---|
| Gene Name | FGD5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1462 |
| Protein Names | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000154783 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6ZNL6 |
| Gene Card | FGD5 |
| Uniprot ID | Q6ZNL6 |
| Pfam | PF01363; PF00169; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-1.551486281) |
| Ortholog in Animals | Alpaca_ FGD5 ( ortholog_one2one ) Dog_ FGD5 ( ortholog_one2one ) GuineaPig_ FGD5 ( ortholog_one2one ) Macaque_ FGD5 ( ortholog_one2one ) Mouse_ Fgd5 ( ortholog_one2one ) Pig_ FGD5 ( ortholog_one2one ) Rat_ Fgd5 ( ortholog_one2one ) Rabbit_ FGD5 ( ortholog_one2one ) |
| Ohnologs | FGD6 |
| Paralogs | ECT2L, ARHGEF39, FARP1, FARP2, FGD6, FGD4, FGD3, FGD2, FRMD7, FGD1 |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelial cells (at protein level). {ECO:0000269|PubMed:22328776}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3MPX (X-ray 2.80A ) |
| DBSNP | rs7636593 rs17038795 rs2307092 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22328776}. Endoplasmic reticulum {ECO:0000269|PubMed:22328776}. Golgi apparatus {ECO:0000269|PubMed:22328776}. Early endosome {ECO:0000269|PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5. |
| Mouse PG classification | NA |
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