| Gene Information | |
|---|---|
| Gene Name | FGD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 766 |
| Protein Names | FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000139132 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96M96 |
| Gene Card | FGD4 |
| Uniprot ID | Q96M96 |
| Pfam | PF01363; PF00169; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.727822285) |
| Ortholog in Animals | Alpaca_ FGD4 ( ortholog_one2one ) Dog_ FGD4 ( ortholog_one2one ) GuineaPig_ FGD4 ( ortholog_one2one ) Macaque_ FGD4 ( ortholog_one2one ) Mouse_ Fgd4 ( ortholog_one2one ) Pig_ FGD4 ( ortholog_one2one ) Rat_ Fgd4 ( ortholog_one2one ) Rabbit_ FGD4 ( ortholog_one2one ) |
| Ohnologs | FGD1, FGD6, FGD3, FGD2 |
| Paralogs | ECT2L, ARHGEF39, FGD5, FARP1, FARP2, FGD6, FGD3, FGD2, FRMD7, FGD1 |
| Tissue | NA |
| Tissue Specificity | Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis. {ECO:0000269|PubMed:17564959}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs63749871 rs63749871 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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