| Gene Information | |
|---|---|
| Gene Name | FGD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000146192 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z6J4 |
| Gene Card | FGD2 |
| Uniprot ID | Q7Z6J4 |
| Pfam | PF01363; PF00169; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.999220569) |
| Ortholog in Animals | Alpaca_ FGD2 ( ortholog_one2one ) Dog_ FGD2 ( ortholog_one2one ) GuineaPig_ FGD2 ( ortholog_one2one ) Macaque_ FGD2 ( ortholog_one2one ) Mouse_ Fgd2 ( ortholog_one2one ) Pig_ FGD2 ( ortholog_one2one ) Rat_ Fgd2 ( ortholog_one2one ) Rabbit_ FGD2 ( ortholog_one2one ) |
| Ohnologs | FGD1, FGD4, FGD6 |
| Paralogs | ECT2L, ARHGEF39, FGD5, FARP1, FARP2, FGD6, FGD4, FGD3, FRMD7, FGD1 |
| Tissue | spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs831510 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Early endosome {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. {ECO:0000250}. |
| Mouse PG classification | NA |
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