| Gene Information | |
|---|---|
| Gene Name | FGB |
| Organism | Homo sapiens (Human) |
| Gene Length | 491 |
| Protein Names | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] |
| Target Name | fibrinogen beta chain |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171564 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02675 |
| Gene Card | FGB |
| Uniprot ID | P02675 |
| Pfam | PF08702; PF00147 |
| In ASD | yes |
| Allosteric Prediction | yes (1.725464491) |
| Ortholog in Animals | Alpaca_ FGB ( ortholog_one2one ) Dog_ FGB ( ortholog_one2one ) GuineaPig_ FGB ( ortholog_one2one ) Macaque_ FGB ( ortholog_one2one ) Mouse_ Fgb ( ortholog_one2one ) Pig_ FGB ( ortholog_one2one ) Rat_ Fgb ( ortholog_one2one ) Rabbit_ FGB ( ortholog_one2one ) |
| Ohnologs | FGL1 |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2 |
| Tissue | liver |
| Tissue Specificity | Detected in blood plasma (at protein level). {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.445042(Rat);0.040741(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FZA (X-ray 2.90A ) 1FZB (X-ray 2.90A ) 1FZC (X-ray 2.30A ) 1FZE (X-ray 3.00A ) 1FZF (X-ray 2.70A ) 1FZG (X-ray 2.50A ) 1LT9 (X-ray 2.80A ) 1LTJ (X-ray 2.80A ) 1N86 (X-ray 3.20A ) 1N8E (X-ray 4.50A ) 1RE3 (X-ray 2.45A ) 1RE4 (X-ray 2.70A ) 1RF0 (X-ray 2.81A ) 1RF1 (X-ray 2.53A ) 2A45 (X-ray 3.65A ) 2FFD (X-ray 2.89A ) 2H43 (X-ray 2.70A ) 2HLO (X-ray 2.60A ) 2HOD (X-ray 2.90A ) 2HPC (X-ray 2.90A ) 2OYH (X-ray 2.40A ) 2OYI (X-ray 2.70A ) 2Q9I (X-ray 2.80A ) 2XNX (X-ray 3.30A ) 2XNY (X-ray 7.50A ) 2Z4E (X-ray 2.70A ) 3BVH (X-ray 2.60A ) 3E1I (X-ray 2.30A ) 3GHG (X-ray 2.90A ) 3H32 (X-ray 3.60A ) 3HUS (X-ray 3.04A ) 6ATZ (X-ray 2.70A ) 6BIJ (X-ray 2.10A ) 6BIL (X-ray 2.40A ) 6V0Y (X-ray 2.70A ) 6V13 (X-ray 2.75A ) 6V15 (X-ray 2.80A ) 6V18 (X-ray 2.35A ) 6V19 (X-ray 2.60A ) 6V1A (X-ray 2.29A ) |
| DBSNP | rs6053 rs121909616 rs121909619 rs121909620 rs2227434 rs2227409 rs121909623 rs121909624 rs6054 rs121909617 rs121909621 rs121909622 rs4220 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Mouse PG classification | NA |
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