| Gene Information | |
|---|---|
| Gene Name | FGA |
| Organism | Homo sapiens (Human) |
| Gene Length | 866 |
| Protein Names | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] |
| Target Name | fibrinogen |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000171560 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02671 |
| Gene Card | FGA |
| Uniprot ID | P02671 |
| Pfam | PF08702; PF12160; PF00147 |
| In ASD | yes |
| Allosteric Prediction | yes (1.330862968) |
| Ortholog in Animals | Alpaca_ FGA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2, ANGPTL2 |
| Tissue | liver |
| Tissue Specificity | Detected in blood plasma (at protein level). {ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BBR (X-ray 2.30A ) 1DM4 (X-ray 2.50A ) 1FPH (X-ray 2.50A ) 1FZA (X-ray 2.90A ) 1FZB (X-ray 2.90A ) 1FZC (X-ray 2.30A ) 1FZD (X-ray 2.10A ) 1FZE (X-ray 3.00A ) 1FZF (X-ray 2.70A ) 1FZG (X-ray 2.50A ) 1LT9 (X-ray 2.80A ) 1LTJ (X-ray 2.80A ) 1N86 (X-ray 3.20A ) 1N8E (X-ray 4.50A ) 1RE3 (X-ray 2.45A ) 1RE4 (X-ray 2.70A ) 1RF0 (X-ray 2.81A ) 1RF1 (X-ray 2.53A ) 1YCP (X-ray 2.50A ) 2A45 (X-ray 3.65A ) 2FFD (X-ray 2.89A ) 2H43 (X-ray 2.70A ) 2HLO (X-ray 2.60A ) 2HOD (X-ray 2.90A ) 2HPC (X-ray 2.90A ) 2OYH (X-ray 2.40A ) 2OYI (X-ray 2.70A ) 2Q9I (X-ray 2.80A ) 2XNX (X-ray 3.30A ) 2XNY (X-ray 7.50A ) 2Z4E (X-ray 2.70A ) 3AT0 (X-ray 2.50A ) 3BVH (X-ray 2.60A ) 3E1I (X-ray 2.30A ) 3GHG (X-ray 2.90A ) 3H32 (X-ray 3.60A ) 3HUS (X-ray 3.04A ) 4F27 (X-ray 1.92A ) 5CFA (X-ray 1.45A ) |
| DBSNP | rs2070025 rs121909604 rs121909605 rs121909606 rs121909607 rs121909609 rs121909608 rs1403508334 rs121909614 rs6050 rs6052 rs121909610 rs2070031 rs121909612 rs121909613 rs78506343 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}. |
| Mouse PG classification | NA |
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