| Gene Information | |
|---|---|
| Gene Name | FEX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2551 |
| Protein Names | Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WWQ8 |
| Gene Card | STAB2 |
| Uniprot ID | Q8WWQ8 |
| Pfam | PF12947; PF02469; PF00193 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. {ECO:0000269|PubMed:11829752, ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:12626425, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5N86 (X-ray 1.48A ) |
| DBSNP | rs17034186 rs12319476 rs1609860 rs17034336 rs7973658 rs17034433 rs7306642 rs2271637 rs3751197 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17675564}; Single-pass type I membrane protein {ECO:0000269|PubMed:17675564}. Cytoplasm {ECO:0000269|PubMed:17145755}. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755). |
| Mouse PG classification | NA |
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