| Gene Information | |
|---|---|
| Gene Name | FEV |
| Organism | Homo sapiens (Human) |
| Gene Length | 238 |
| Protein Names | Protein FEV (Fifth Ewing variant protein) (PC12 ETS domain-containing transcription factor 1) (PC12 ETS factor 1) (Pet-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163497 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99581 |
| Gene Card | FEV |
| Uniprot ID | Q99581 |
| Pfam | PF00178 |
| In ASD | no |
| Allosteric Prediction | no (-0.739306915) |
| Ortholog in Animals | Alpaca_ FEV ( ortholog_one2one ) Dog_ FEV ( ortholog_one2one ) GuineaPig_ FEV ( ortholog_one2one ) Macaque_ FEV ( ortholog_one2one ) Mouse_ Fev ( ortholog_one2one ) Pig_ FEV ( ortholog_one2one ) Rat_ Fev ( ortholog_one2one ) Rabbit_ FEV ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ETS1, ELF2, SPI1, ELK4, ELF1, SPIB, SPIC, ERFL, SPDEF |
| Tissue | NA |
| Tissue Specificity | In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine. {ECO:0000269|PubMed:15003288, ECO:0000269|PubMed:15986391, ECO:0000269|PubMed:9121764}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YPR (X-ray 2.64A ) 3ZP5 (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:12761502}. |
| Mouse PG classification | NA |
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