| Gene Information | |
|---|---|
| Gene Name | FERMT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 677 |
| Protein Names | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000101311 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BQL6 |
| Gene Card | FERMT1 |
| Uniprot ID | Q9BQL6 |
| Pfam | PF00373; PF18124; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.872370634) |
| Ortholog in Animals | Alpaca_ FERMT1 ( ortholog_one2one ) Dog_ FERMT1 ( ortholog_one2one ) GuineaPig_ FERMT1 ( ortholog_one2one ) Macaque_ FERMT1 ( ortholog_one2one ) Mouse_ Fermt1 ( ortholog_one2one ) Pig_ FERMT1 ( ortholog_one2one ) Rat_ Fermt1 ( ortholog_one2one ) Rabbit_ FERMT1 ( ortholog_one2one ) |
| Ohnologs | FERMT2, FERMT3 |
| Paralogs | FERMT3, FERMT2 |
| Tissue | adrenal.gland, esophagus.mucosa, lower.leg.skin, suprapubic.skin, transverse.colon |
| Tissue Specificity | Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts. {ECO:0000269|PubMed:12668616, ECO:0000269|PubMed:12697302, ECO:0000269|PubMed:12789646, ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16991866 rs55666319 rs869312718 rs2232074 rs2232078 rs869312719 rs869312721 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles. |
| Mouse PG classification | NA |
| click here to return to the previous page | |