| Gene Information | |
|---|---|
| Gene Name | FECH |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase) |
| Target Name | ferrochelatase, mitochondrial |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000066926 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P22830 |
| Gene Card | FECH |
| Uniprot ID | P22830 |
| Pfam | PF00762 |
| In ASD | no |
| Allosteric Prediction | yes (0.777352391) |
| Ortholog in Animals | Alpaca_ FECH ( ortholog_one2one ) Dog_ FECH ( ortholog_one2one ) GuineaPig_ FECH ( ortholog_one2one ) Macaque_ FECH ( ortholog_one2one ) Mouse_ Fech ( ortholog_one2one ) Pig_ FECH ( ortholog_one2one ) Rat_ Fech ( ortholog_one2one ) Rabbit_ FECH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HRK (X-ray 2.00A ) 2HRC (X-ray 1.70A ) 2HRE (X-ray 2.50A ) 2PNJ (X-ray 2.35A ) 2PO5 (X-ray 2.20A ) 2PO7 (X-ray 2.20A ) 2QD1 (X-ray 2.20A ) 2QD2 (X-ray 2.20A ) 2QD3 (X-ray 2.20A ) 2QD4 (X-ray 2.00A ) 2QD5 (X-ray 2.30A ) 3AQI (X-ray 1.70A ) 3HCN (X-ray 1.60A ) 3HCO (X-ray 1.80A ) 3HCP (X-ray 2.00A ) 3HCR (X-ray 2.20A ) 3W1W (X-ray 2.01A ) 4F4D (X-ray 1.80A ) 4KLA (X-ray 2.60A ) 4KLC (X-ray 2.40A ) 4KLR (X-ray 2.18A ) 4KMM (X-ray 2.60A ) 4MK4 (X-ray 2.50A ) 7CT7 (X-ray 2.00A ) 7CTC (X-ray 2.00A ) |
| DBSNP | rs3848519 rs150830931 rs1041951 rs1356965294 rs1160565035 rs1598996367 rs1055019947 rs761962617 rs118204037 rs150146721 rs118204040 rs1324421474 rs118204039 |
| Subcellular location [CC] | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Mouse PG classification | HPG |
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