| Gene Information | |
|---|---|
| Gene Name | FE65 |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O00213 |
| Gene Card | APBB1 |
| Uniprot ID | O00213 |
| Pfam | PF00640; PF00397 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. {ECO:0000269|PubMed:19343227}.; [Isoform 4]: Expressed preferentially in the brain. {ECO:0000269|PubMed:21824145}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E45 (NMR - ) 2HO2 (X-ray 1.33A ) 2IDH (X-ray 2.28A ) 2OEI (X-ray 1.35A ) 3D8D (X-ray 2.20A ) 3D8E (X-ray 2.80A ) 3D8F (X-ray 2.70A ) 3DXC (X-ray 2.10A ) 3DXD (X-ray 2.20A ) 3DXE (X-ray 2.00A ) 5NQH (X-ray 2.60A ) |
| DBSNP | rs1800423 rs1800425 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18468999}. Cytoplasm {ECO:0000269|PubMed:18468999}. Nucleus {ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250|UniProtKB:P46933}. Nucleus speckle {ECO:0000269|PubMed:17512906}. Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). {ECO:0000250|UniProtKB:P46933, ECO:0000269|PubMed:17512906, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:19343227}. |
| Mouse PG classification | NA |
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