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Gene Information
Gene Name
FDPS
Organism
Homo sapiens (Human)
Gene Length
419
Protein Names
Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)
Target Name
geranyltranstransferase
Target Type
Successful target
Gene Age
645 ( ENSG00000160752 )
Evolutionary Stage
Euk+Bac
AlphaFoldDB
P14324
Gene Card
FDPS
Uniprot ID
P14324
Pfam
PF00348
In ASD
yes
Allosteric Prediction
yes (1.000304045)
Ortholog in Animals
Alpaca_ FDPS ( ortholog_one2one )
Dog_ FDPS ( ortholog_one2one )
GuineaPig_ FDPS ( ortholog_one2one )
Macaque_ FDPS ( ortholog_one2many )
Mouse_ Fdps ( ortholog_one2one )
Pig_ FDPS ( ortholog_one2one )
Rabbit_ FDPS ( ortholog_one2one )
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1YQ7
(X-ray
2.20A
)
1YV5
(X-ray
2.00A
)
1ZW5
(X-ray
2.30A
)
2F7M
(X-ray
2.30A
)
2F89
(X-ray
2.60A
)
2F8C
(X-ray
2.20A
)
2F8Z
(X-ray
2.60A
)
2F92
(X-ray
2.15A
)
2F94
(X-ray
1.94A
)
2F9K
(X-ray
2.06A
)
2OPM
(X-ray
2.40A
)
2OPN
(X-ray
2.70A
)
2QIS
(X-ray
1.80A
)
2RAH
(X-ray
2.00A
)
2VF6
(X-ray
2.10A
)
3B7L
(X-ray
1.95A
)
3CP6
(X-ray
1.95A
)
3N1V
(X-ray
2.18A
)
3N1W
(X-ray
2.56A
)
3N3L
(X-ray
2.74A
)
3N45
(X-ray
1.88A
)
3N46
(X-ray
2.35A
)
3N49
(X-ray
2.50A
)
3N5H
(X-ray
2.20A
)
3N5J
(X-ray
2.35A
)
3N6K
(X-ray
2.25A
)
3RYE
(X-ray
2.10A
)
3S4J
(X-ray
1.95A
)
4DEM
(X-ray
1.85A
)
4GA3
(X-ray
2.39A
)
4H5C
(X-ray
2.02A
)
4H5D
(X-ray
2.02A
)
4H5E
(X-ray
2.04A
)
4JVJ
(X-ray
2.80A
)
4KFA
(X-ray
1.98A
)
4KPD
(X-ray
1.96A
)
4KPJ
(X-ray
1.95A
)
4KQ5
(X-ray
2.40A
)
4KQS
(X-ray
1.97A
)
4KQU
(X-ray
2.07A
)
4L2X
(X-ray
2.55A
)
4LFV
(X-ray
2.00A
)
4LPG
(X-ray
2.35A
)
4LPH
(X-ray
2.30A
)
4N1Z
(X-ray
2.35A
)
4N9U
(X-ray
2.11A
)
4NFI
(X-ray
1.85A
)
4NFJ
(X-ray
2.05A
)
4NFK
(X-ray
1.85A
)
4NG6
(X-ray
2.35A
)
4NKE
(X-ray
1.46A
)
4NKF
(X-ray
2.00A
)
4NUA
(X-ray
1.43A
)
4OGU
(X-ray
2.10A
)
4P0V
(X-ray
2.40A
)
4P0W
(X-ray
2.41A
)
4P0X
(X-ray
2.50A
)
4PVX
(X-ray
2.18A
)
4PVY
(X-ray
2.05A
)
4Q23
(X-ray
1.98A
)
4QPF
(X-ray
1.59A
)
4QXS
(X-ray
1.90A
)
4RXA
(X-ray
2.20A
)
4XQR
(X-ray
2.15A
)
4XQS
(X-ray
2.30A
)
4XQT
(X-ray
2.10A
)
5CG5
(Other
1.40A
)
5CG6
(Other
1.70A
)
5DGM
(X-ray
2.86A
)
5DGN
(X-ray
2.08A
)
5DGS
(X-ray
2.62A
)
5DIQ
(X-ray
2.10A
)
5DJP
(X-ray
2.40A
)
5DJR
(X-ray
2.40A
)
5DJV
(X-ray
2.30A
)
5JA0
(X-ray
1.90A
)
5JUZ
(X-ray
2.40A
)
5JV0
(X-ray
2.40A
)
5JV1
(X-ray
2.30A
)
5JV2
(X-ray
2.30A
)
5KSX
(X-ray
2.65A
)
5YGI
(X-ray
2.18A
)
6N7Y
(X-ray
2.00A
)
6N7Z
(X-ray
2.55A
)
6N82
(X-ray
2.00A
)
6N83
(X-ray
2.00A
)
6OAG
(X-ray
2.30A
)
6OAH
(X-ray
2.20A
)
DBSNP
rs863225241
rs41314549
rs17456
Subcellular location [CC]
Cytoplasm.
Mouse PG classification
NA
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