Gene Information
Gene NameFDFT1
OrganismHomo sapiens (Human)
Gene Length417
Protein NamesSqualene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1)
Target Namesqualene synthase
Target TypeNA
Gene Age645 ( ENSG00000079459 )
3 ( ENSG00000284967 )
Evolutionary StageCellular_organisms
AlphaFoldDBP37268
Gene CardFDFT1
Uniprot IDP37268
PfamPF00494
In ASDno
Allosteric Predictionyes (0.261980155)
Ortholog in AnimalsAlpaca_ FDFT1 ( ortholog_one2one )
Dog_ FDFT1 ( ortholog_one2one )
GuineaPig_ FDFT1 ( ortholog_one2one )
Macaque_ FDFT1 ( ortholog_one2one )
Mouse_ Fdft1 ( ortholog_one2one )
Pig_ FDFT1 ( ortholog_one2one )
Rat_ Fdft1 ( ortholog_one2one )
Rabbit_ FDFT1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:29909962}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1EZF  (X-ray  2.15A  )  3ASX  (X-ray  2.00A  )  3LEE  (X-ray  3.20A  )  3Q2Z  (X-ray  2.00A  )  3Q30  (X-ray  2.00A  )  3V66  (X-ray  1.80A  )  3VJ8  (X-ray  1.52A  )  3VJ9  (X-ray  1.52A  )  3VJA  (X-ray  1.76A  )  3VJB  (X-ray  2.05A  )  3VJC  (X-ray  1.89A  )  3WC9  (X-ray  2.82A  )  3WCD  (X-ray  2.75A  )  3WCF  (X-ray  2.22A  )  3WCH  (X-ray  2.50A  )  3WCI  (X-ray  2.30A  )  3WCJ  (X-ray  2.20A  )  3WCL  (X-ray  2.24A  )  3WCM  (X-ray  2.06A  )  3WEF  (X-ray  2.35A  )  3WEG  (X-ray  1.75A  )  3WEH  (X-ray  1.87A  )  3WEI  (X-ray  1.79A  )  3WEJ  (X-ray  2.00A  )  3WEK  (X-ray  1.85A  )  3WSA  (X-ray  2.90A  )  6PYJ  (X-ray  1.44A  )  6PYV  (X-ray  1.45A  )  6PYW  (X-ray  1.38A  )  6PZ5  (X-ray  1.53A  ) 
DBSNP rs4731  rs1804473 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02769};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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