| Gene Information | |
|---|---|
| Gene Name | FDC |
| Organism | Homo sapiens (Human) |
| Gene Length | 525 |
| Protein Names | Lymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P18627 |
| Gene Card | LAG3 |
| Uniprot ID | P18627 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. {ECO:0000269|PubMed:1380059, ECO:0000269|PubMed:1692078, ECO:0000269|PubMed:20421648}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7TZG (X-ray 3.71A ) 7TZH (X-ray 2.43A ) 7UM3 (X-ray 2.40A ) |
| DBSNP | rs870849 |
| Subcellular location [CC] | [Lymphocyte activation gene 3 protein]: Cell membrane {ECO:0000269|PubMed:1380059, ECO:0000269|PubMed:1692078, ECO:0000269|PubMed:9634475}; Single-pass type I membrane protein {ECO:0000255}.; [Secreted lymphocyte activation gene 3 protein]: Secreted {ECO:0000250|UniProtKB:Q61790}. Note=Produced following cleavage of the main chain. {ECO:0000250|UniProtKB:Q61790}. |
| Mouse PG classification | NA |
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