| Gene Information | |
|---|---|
| Gene Name | FCRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P55899 |
| Gene Card | FCGRT |
| Uniprot ID | P55899 |
| Pfam | PF07654; PF00129 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine. {ECO:0000269|PubMed:28330995, ECO:0000269|PubMed:7964511}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EXU (X-ray 2.70A ) 3M17 (X-ray 2.60A ) 3M1B (X-ray 3.10A ) 4K71 (X-ray 2.40A ) 4N0F (X-ray 3.02A ) 4N0U (X-ray 3.80A ) 5BJT (X-ray 3.20A ) 5BXF (X-ray 2.85A ) 5WHK (X-ray 2.50A ) 6C97 (X-ray 2.00A ) 6C98 (X-ray 1.85A ) 6C99 (X-ray 2.00A ) 6FGB (X-ray 2.90A ) 6ILM (EM 3.40A ) 6LA6 (EM 2.39A ) 6LA7 (EM 2.82A ) 6NHA (X-ray 2.38A ) 6QIO (X-ray 1.95A ) 6QIP (X-ray 2.45A ) 6WNA (X-ray 2.40A ) 6WOL (X-ray 2.49A ) 7B5F (EM 2.90A ) 7C9V (EM 3.30A ) 7XXA (EM 3.09A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:31104841}. |
| Mouse PG classification | NA |
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