| Gene Information | |
|---|---|
| Gene Name | FCN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen) |
| Target Name | ficolin-3 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000142748 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75636 |
| Gene Card | FCN3 |
| Uniprot ID | O75636 |
| Pfam | PF00147 |
| In ASD | no |
| Allosteric Prediction | no (-0.619821408) |
| Ortholog in Animals | Alpaca_ FCN3 ( ortholog_one2one ) Macaque_ FCN3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2 |
| Tissue | liver, lung |
| Tissue Specificity | Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269|PubMed:10330454}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2J5Z (X-ray 1.73A ) 2J60 (X-ray 1.80A ) 2J64 (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct. |
| Mouse PG classification | NA |
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