Gene Information
Gene NameFCN1
OrganismHomo sapiens (Human)
Gene Length326
Protein NamesFicolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000085265 )
Evolutionary StageEumetazoa
AlphaFoldDBO00602
Gene CardFCN1
Uniprot IDO00602
PfamPF01391; PF00147
In ASDno
Allosteric Predictionno (-0.279867208)
Ortholog in AnimalsAlpaca_ FCN1 ( ortholog_one2one )
Dog_ FCN2 ( ortholog_one2one )
GuineaPig_ FCN1 ( ortholog_one2one )
Macaque_ FCN1 ( ortholog_one2one )
Mouse_ Fcnb ( ortholog_one2one )
Rat_ Fcnb ( ortholog_one2one )
OhnologsNA
ParalogsTNC, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2
Tissueappendix, bone.marrow, lung, spleen, whole.blood
Tissue SpecificityPeripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2D39  (X-ray  1.90A  )  2JHH  (X-ray  1.70A  )  2JHI  (X-ray  1.80A  )  2JHK  (X-ray  1.75A  )  2JHL  (X-ray  1.75A  )  2JHM  (X-ray  1.52A  )  2WNP  (X-ray  1.21A  ) 
DBSNP rs56345770  rs771359747 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Cell membrane {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097};
Peripheral membrane protein {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097};
Extracellular side {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Note=Found on the monocyte and granulocyte surface (PubMed:20400674).
Mouse PG classificationNA
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