| Gene Information | |
|---|---|
| Gene Name | HMGCR |
| Organism | Homo sapiens (Human) |
| Gene Length | 888 |
| Protein Names | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) |
| Target Name | hmg-coa reductase |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000113161 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P04035 |
| Gene Card | HMGCR |
| Uniprot ID | P04035 |
| Pfam | PF00368; PF12349 |
| In ASD | no |
| Allosteric Prediction | yes (1.629652511) |
| Ortholog in Animals | Alpaca_ HMGCR ( ortholog_one2one ) Dog_ HMGCR ( ortholog_one2one ) GuineaPig_ HMGCR ( ortholog_one2one ) Macaque_ HMGCR ( ortholog_one2one ) Mouse_ Hmgcr ( ortholog_one2one ) Pig_ HMGCR ( ortholog_one2one ) Rat_ Hmgcr ( ortholog_one2one ) Rabbit_ HMGCR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. {ECO:0000269|PubMed:22989091}.; [Isoform 2]: Detected in the cerebellum, fetal brain, testis and adrenal gland. {ECO:0000269|PubMed:22989091}.; [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix. {ECO:0000269|PubMed:22989091}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1DQ8 (X-ray 2.10A ) 1DQ9 (X-ray 2.80A ) 1DQA (X-ray 2.00A ) 1HW8 (X-ray 2.10A ) 1HW9 (X-ray 2.33A ) 1HWI (X-ray 2.30A ) 1HWJ (X-ray 2.26A ) 1HWK (X-ray 2.22A ) 1HWL (X-ray 2.10A ) 2Q1L (X-ray 2.05A ) 2Q6B (X-ray 2.00A ) 2Q6C (X-ray 2.00A ) 2R4F (X-ray 1.70A ) 3BGL (X-ray 2.23A ) 3CCT (X-ray 2.12A ) 3CCW (X-ray 2.10A ) 3CCZ (X-ray 1.70A ) 3CD0 (X-ray 2.40A ) 3CD5 (X-ray 2.39A ) 3CD7 (X-ray 2.05A ) 3CDA (X-ray 2.07A ) 3CDB (X-ray 2.30A ) |
| DBSNP | rs5908 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17180682, ECO:0000305|PubMed:2991281}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane {ECO:0000269|PubMed:17180682}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. |
| Mouse PG classification | NA |
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