Gene Information
Gene NameFCGR3A
OrganismHomo sapiens (Human)
Gene Length254
Protein NamesLow affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Target Nameimmunoglobulin gamma fc receptor iiia
Target TypeClinical trial target
Gene Age544 ( ENSG00000203747 )
Evolutionary StageEumetazoa
AlphaFoldDBP08637
Gene CardFCGR3A
Uniprot IDP08637
PfamPF13895
In ASDno
Allosteric Predictionyes (0.425873908)
Ortholog in AnimalsMouse_ Fcgr4 ( ortholog_one2many )
Rat_ Fcgr3a ( ortholog_one2many )
OhnologsNA
ParalogsPECAM1, FCGR3B, FCGR2A, FCGR2B, FCGR2C, FCER1A, FCGR1A, C17orf99, FCRLA, FCRLB, FCRL6, FCRL5, FCRL4, MILR1, FCRL2, FCRL3, FCRL1
TissueNA
Tissue SpecificityExpressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:27670158). {ECO:0000269|PubMed:2526846, ECO:0000269|PubMed:27670158}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3AY4  (X-ray  2.20A  )  3SGJ  (X-ray  2.20A  )  3SGK  (X-ray  2.40A  )  3WN5  (X-ray  2.78A  )  5BW7  (X-ray  3.00A  )  5D6D  (X-ray  3.13A  )  5ML9  (X-ray  2.35A  )  5MN2  (X-ray  2.35A  )  5VU0  (X-ray  2.26A  )  5XJE  (X-ray  2.40A  )  5XJF  (X-ray  2.50A  )  5YC5  (X-ray  2.71A  )  7SEG  (X-ray  2.16A  ) 
DBSNP rs10127939  rs10127939  rs443082  rs396716  rs396991  rs1042206 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:1825220, ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:2532305, ECO:0000269|PubMed:28652325, ECO:0000269|PubMed:29967280};
Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}. Note=Exists also as a soluble receptor. {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}.
Mouse PG classificationNA
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