| Gene Information | |
|---|---|
| Gene Name | FCGR2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32) |
| Target Name | immunoglobulin gamma fc receptor iia |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000143226 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P12318 |
| Gene Card | FCGR2A |
| Uniprot ID | P12318 |
| Pfam | PF13895 |
| In ASD | no |
| Allosteric Prediction | yes (0.454842993) |
| Ortholog in Animals | Mouse_ Fcgr2b ( ortholog_many2many ) Mouse_ Fcgr3 ( ortholog_many2many ) Rat_ Fcgr2a ( ortholog_many2many ) Rat_ Fcgr2b ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | PECAM1, FCGR2B, FCGR2C, FCGR3B, FCGR3A, FCER1A, FCGR1A, C17orf99, FCRLA, FCRLB, FCRL6, FCRL5, FCRL4, MILR1, FCRL2, FCRL3, FCRL1 |
| Tissue | NA |
| Tissue Specificity | Found on monocytes, neutrophils and eosinophil platelets. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FCG (X-ray 2.00A ) 1H9V (X-ray 3.00A ) 3D5O (X-ray 2.80A ) 3RY4 (X-ray 1.50A ) 3RY5 (X-ray 2.30A ) 3RY6 (X-ray 3.80A ) |
| DBSNP | rs9427398 rs4986941 rs1801274 rs17851834 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}. |
| Mouse PG classification | NA |
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