| Gene Information | |
|---|---|
| Gene Name | PTPN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1) |
| Target Name | tyrosine-protein phosphatase non-receptor type 4 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000088179 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P29074 |
| Gene Card | PTPN4 |
| Uniprot ID | P29074 |
| Pfam | PF08736; PF09380; PF00373; PF09379; PF00595; PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (1.123138354) |
| Ortholog in Animals | Alpaca_ PTPN4 ( ortholog_one2one ) Dog_ PTPN4 ( ortholog_one2one ) GuineaPig_ PTPN4 ( ortholog_one2one ) Macaque_ PTPN4 ( ortholog_one2one ) Mouse_ Ptpn4 ( ortholog_one2one ) Pig_ PTPN4 ( ortholog_one2one ) Rat_ Ptpn4 ( ortholog_one2one ) Rabbit_ PTPN4 ( ortholog_one2one ) |
| Ohnologs | PTPN3 |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CS5 (NMR - ) 2I75 (X-ray 2.45A ) 2VPH (X-ray 1.90A ) 3NFK (X-ray 1.43A ) 3NFL (X-ray 1.91A ) 5EYZ (X-ray 2.09A ) 5EZ0 (X-ray 2.35A ) 7VZE (X-ray 2.88A ) |
| DBSNP | rs3189128 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:8910369}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8910369}. Cytoplasm {ECO:0000269|PubMed:20086240, ECO:0000269|PubMed:8910369}. |
| Mouse PG classification | NA |
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