| Gene Information | |
|---|---|
| Gene Name | FCAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 287 |
| Protein Names | Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89) |
| Target Name | immunoglobulin alpha fc receptor |
| Target Type | Discontinued target |
| Gene Age | 382 ( ENSG00000186431 ) 3 ( ENSG00000273738 ) 3 ( ENSG00000274580 ) 3 ( ENSG00000275136 ) 3 ( ENSG00000275269 ) 3 ( ENSG00000275564 ) 3 ( ENSG00000275970 ) 3 ( ENSG00000276858 ) 3 ( ENSG00000276985 ) 3 ( ENSG00000278415 ) 3 ( ENSG00000283750 ) 3 ( ENSG00000283953 ) 3 ( ENSG00000284004 ) 3 ( ENSG00000284061 ) 3 ( ENSG00000284245 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P24071 |
| Gene Card | FCAR |
| Uniprot ID | P24071 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.114871086) |
| Ortholog in Animals | Alpaca_ FCAR ( ortholog_one2many ) Macaque_ FCAR ( ortholog_one2one ) Pig_ FCAR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KIR2DL3, KIR3DL3, KIR3DL2, KIR3DL1, KIR2DS4, KIR2DL4, KIR2DL1, LILRB2, LILRB5, LILRA2, LILRA4, LILRA6, LILRA5, NCR1, LILRB4, LILRB1, LILRA1, LILRB3, GP6, IGSF1, OSCAR, TARM1, VSTM1, LAIR2, A1BG |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. {ECO:0000269|PubMed:8666819, ECO:0000269|PubMed:8836118}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OVZ (X-ray 3.00A ) 1OW0 (X-ray 3.10A ) 1UCT (X-ray 2.10A ) |
| DBSNP | rs11666735 rs16986050 |
| Subcellular location [CC] | [Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted. |
| Mouse PG classification | NA |
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