| Gene Information | |
|---|---|
| Gene Name | HNAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 780 |
| Protein Names | Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NR71 |
| Gene Card | ASAH2 |
| Uniprot ID | Q9NR71 |
| Pfam | PF04734; PF17048 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Primarily expressed in intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B (PubMed:17334805). {ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:17334805}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4WGK (X-ray 2.58A ) |
| DBSNP | rs7067625 rs1052952953 |
| Subcellular location [CC] | [Neutral ceramidase]: Cell membrane {ECO:0000269|PubMed:15845354}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane raft {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane, caveola {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Golgi apparatus membrane {ECO:0000269|PubMed:30154232}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Mitochondrion {ECO:0000269|PubMed:10781606}. Secreted, extracellular exosome {ECO:0000269|PubMed:24798654}. Note=Enriched in exosomes upon stimulation by cytokine (PubMed:24798654). Enriched in caveolae and lipid rafts (By similarity). The localization to the mitochondrion could not be confirmed (PubMed:15845354). {ECO:0000250|UniProtKB:Q9JHE3, ECO:0000269|PubMed:15845354, ECO:0000269|PubMed:24798654}.; [Neutral ceramidase soluble form]: Secreted {ECO:0000250|UniProtKB:Q91XT9}. |
| Mouse PG classification | NA |
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