| Gene Information | |
|---|---|
| Gene Name | TPX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 747 |
| Protein Names | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000088325 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9ULW0 |
| Gene Card | TPX2 |
| Uniprot ID | Q9ULW0 |
| Pfam | PF09041; PF06886; PF12214 |
| In ASD | no |
| Allosteric Prediction | yes (0.526117584) |
| Ortholog in Animals | Alpaca_ TPX2 ( ortholog_one2one ) Dog_ TPX2 ( ortholog_one2one ) GuineaPig_ TPX2 ( ortholog_one2one ) Macaque_ TPX2 ( ortholog_one2one ) Mouse_ Tpx2 ( ortholog_one2one ) Pig_ TPX2 ( ortholog_one2one ) Rat_ Tpx2 ( ortholog_one2one ) Rabbit_ TPX2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, bone.marrow, colon, dura.mater, heart, testis, tongue, brain |
| Tissue Specificity | Expressed in lung carcinoma cell lines but not in normal lung tissues. |
| Pharmacological Animal Models | 0.022255(Chimpanzee);0.001000(Mouse);0.001990(Rat);0.040000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1OL5 (X-ray 2.50A ) 3E5A (X-ray 2.30A ) 3HA6 (X-ray 2.36A ) 4C3P (X-ray 2.69A ) 5LXM (X-ray 2.08A ) 6BJC (EM 3.30A ) 6VPG (X-ray 2.64A ) 6VPH (X-ray 2.14A ) 6VPI (X-ray 2.00A ) 6VPJ (X-ray 2.10A ) 6VPL (X-ray 1.86A ) 6VPM (X-ray 1.58A ) 6XKA (X-ray 2.65A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269|PubMed:19208764}. |
| Mouse PG classification | NA |
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