| Gene Information | |
|---|---|
| Gene Name | FBP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000130957 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O00757 |
| Gene Card | FBP2 |
| Uniprot ID | O00757 |
| Pfam | PF00316; PF18913 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000118383) |
| Ortholog in Animals | Alpaca_ FBP2 ( ortholog_one2one ) Dog_ FBP2 ( ortholog_one2one ) GuineaPig_ FBP2 ( ortholog_one2one ) Mouse_ Fbp2 ( ortholog_one2one ) Pig_ FBP2 ( ortholog_one2one ) Rat_ Fbp2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FBP1 |
| Tissue | stomach, skeletal.muscle, artery |
| Tissue Specificity | Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:12507293}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3IFA (X-ray 1.93A ) 3IFC (X-ray 1.97A ) 4HE0 (X-ray 2.69A ) 4HE1 (X-ray 2.23A ) 4HE2 (X-ray 1.60A ) 5ET5 (X-ray 1.67A ) 5ET6 (X-ray 1.84A ) 5ET7 (X-ray 2.99A ) 5ET8 (X-ray 1.92A ) 5K54 (X-ray 1.72A ) 5K55 (X-ray 1.98A ) 5K56 (X-ray 2.20A ) 5L0A (X-ray 2.30A ) 5Q0C (X-ray 2.40A ) |
| DBSNP | rs573212 |
| Subcellular location [CC] | Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |